Abstract

The polycystic ovary syndrome (PCOS) is one of the most common reproductive abnormalities, affecting 5–10% of the population in the reproductive age. Interleukin-10 (IL-10), a major proinflammatory cytokinein chronic inflammation also called human cytokine synthesis inhibitory factor (CSIF), has been shown to be closely associated with insulin resistant ( IR ), low level of anti-mullerian hormone (AMH), body mass index ( BMI ) and cardiovascular abnormalities.
The change of serum Interlukin-10 ( IL-10 ) levels in women with  polycystic ovary syndrome (PCOS), as well as the relations between IL-10 levels and body mass index (BMI) and anti-mullerian hormone (AMH) in PCOS patients, are not fully understood.
Objective:
The aim of this study was to evaluate serum concentrations of interleukin-10 (IL-10) in relation with hormonal changes and high body mass index (BMI) in patients with and without polycystic ovary syndrome (PCOS).
Material and Methods:
 In this study, 200 Iraqi women aged between 20-50 years were studied. The patients were divided into two groups: study group (n=100, PCOS women) and age-matched controls group (n=100 normal women). The blood sample was obtained on the 2nd day of menstruation cycle. IL-10 concentrations were determined in both groups.
Results:
Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-10 levels more than controls (p < 0.05); however, levels of IL-10 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-10 levels were significantly correlated positively with BMI and low anti-mullerian hormone (AMH) levels.
Conclusion:
The data of this study suggested that serum IL-10 levels were found to be higher in women with PCOS as compared to controls.
 Raised serum IL-10 levels may be related to BMI and AMH levels.