Abstract

 In medicine, nanoparticles are successfully replacing anticancer drugs (NPs). In this study, FeCO3-NPs were produced using the co-precipitation method (A), while the green chemistry method and turmeric extract were employed in the latter (B). Several methods were characterized, including FTIR, XRD, EDX, and SEM. The average size of FeCO3-NPs (A) and FeCO3-NPs (B) particles in the XRD was 26.96 nm and 30.60 nm, respectively. According to EDX, the synthesized NPs have a high degree of purity. FeCO3-NPs (A) were evaluated on HL-60 cells at 25, 50, 100, 200, and 400 µg/ml dosages. Following 24 hours, the killing rate was, in descending order, 39.4%, 61.64%, 78.14%, 91.44%, and 66.344%. And in that sequence, the death rate of ZnCO3-NPs (B) was 18.4%, 28.6%, 42.2 %, 52.5 %, and 80.6 %. Chemical precipitation is a better method for killing or inhibiting. Half-maximal inhibitory doses (IC50) for FeCO3-NPs for A and B are 34.98 and 135.2 µg/ml, respectively. FeCO3-NPs have potential therapeutic advantages as anticancer drugs. The drug was safe at all concentrations (not harmful).