Abstract

The current study was included identify bacterial profile of the oral Streptococci associated with abuse substance in addict patients, Seventy oral swabs were collected from addict patients and twenty samples from healthy (control) with age ranged (19-53 ) years. During the period from August (2019) to February (2020) . Abuse substance were detected by using by Immunoassay (ABON™ Multi-Drug - urine ) which is one step screen test panel used for the qualitative detection of multiple drugs in human urine , Isolation of bacteria was done using the enrichment media , differential media , and selective media , and diagnosed according to some examinations methods which included cultural characteristics , Gram-staining and microscopic examination , biochemical tests , and the final identification was performed with API-20 Strep. and Vitek-2 systems . The results appeared that the Streptococcus spp. were predominant in oral cavity , and the S.mutans of Viridans Streptococci species was more frequent with highest percentage in the addict patients when compared with from the healthy individuals , where the  S. salivarius was more frequent with highest percentage . The conclusion of this study were the alteration of the normal flora in the oral cavity of addict patients which lead to increased susceptibility to opportunistic infectious pathogens.