Abstract

Objective: This study focused on observing the relationship between the gene polymorphism of interleukin-10-1082G/A (rs1800896) and type 2 diabetes mellitus in Iraqi patients from Wasit province with this disease.
Methods: Two milliliters of blood were collected from all samples participating in the study, patient samples were distinguished from healthy samples, and all samples were preserved by deep freezing, then DNA was extracted and genotyping was performed.
Results: This study analyzed the distribution of gene polymorphisms (IL-10-1082G/A) among the studied groups. The genotype (GG) is associated with type 2 diabetes and this genotype increases the risk of developing the disease. The AA genotype reduces the likelihood of developing type 2 diabetes. The genotype (AG) also reduces susceptibility to type 2 diabetes.
Conclusion: According to the results of the current study, interleukin-10 is an important factor in the development of type 2 diabetes, as there may be a link between low levels of interleukin-10 and type 2 diabetes.