Abstract

- one of a chronic inflammatory important is Rheumatoid arthritis(RA) illness that degrades cartilage and, eventually, causes bone erosion and disability. Rheumatoid arthritis, an autoimmune disorder, occurs when your immune system mistakenly attacks your body's own tissues. This ailment has been given the moniker "Objective:" for whatever reason. The fundamental target of this research was to investigate the significance of the VDR SNP (rs7975232) in rheumatoid arthritis patients from Iraq, specifically with regard to fatty acid synthase (FAS) and interleukin-17A. Various Methods: In this study, the demographic information of the participants who had rheumatoid arthritis (RA) and the participants who were healthy served as controls. There were a total of 45 participants with RA and 45 healthy persons. The findings of the study demonstrate that the levels of total cholesterol and LDL cholesterole in the individuals increased significantly (p0.0001 and p0.001, respectively), whilst the levels of HDL cholesterol declined significantly (p0.001 and p0.1, respectively). But neither TG nor VLDL altered in a way that was statistically significant over this time period. According to the findings of the current investigation, there is a statistically significant variance between the  levels of the faty acid  synthase FAS enzyme in the patient's group (0.93 ± .0. 53) and the levels in the control group  (0.74 ± o.45), with a p_ value of 0.001. Comparing the two different sets of values led us to this conclusion. The findings of this research indicate that there is a statisticaly significant gap, with a p_ value of 0.001, between the levels of IL-17A (pg//ml) found in the patients(166/13)and the controle group (87/5). The assessment of both FAS and IL_ 17A has been recommended as a style that is both practicable and helpful for the primary diagnosis of RA patientes in addition the continues tracking of those affected by this disease.