Abstract

Objective: The aim of the current study to evaluate serum levels of (IL-2 , IL-4 and IL-6 ) in chronic renal disease patient before and after hemodialysis.
Material and Methods: Fifty patients with renal failure; Aged 40-70 years were enrolled in the study were collected from Al-Batool Teaching Hospital in Al-Kut, Wasit , Iraq. For comparison, thirty normal persons were examined as a control for all parameters of the patients group. Interleukins IL-2, IL-4 and IL-6 were measured by using ELISA technique.
Results: There was a significant difference in the mean of IL-6 when compare between patients pre and post dialysis (13.72 ± 0.74 vs. 40.14 ± 1.87 pg/ml respectively, p ˂ 0.0001), but there was no significant difference when compare between control (10.64 ± 0.78 pg/ml) and pre-dialysis patients ( p˃0.05). There was a significant difference in IL-2 levels when compare between control and pre-dialysis patients group (2.08 ± 0.10  vs. 3.18 ± 0.08 pg/ml respectively, p ˂ 0.0001), as well as, there was a significant difference when compare between pre and post dialysis patients (3.71 ± 0.11 pg/ml). There was a significant difference between control and post dialysis patients  There was a significant difference in IL-4 levels when compare between control and both pre and post patients groups (1010.47 ± 22.16 mg/dl vs. (1221.50 ± 21.98 & 1673.04 ± 56.19 mg/dl ) respectively, p ˂ 0.0001) and there was a significant difference when compare between pre and post dialysis patients groups.
Conclusion: Both IL-2 and IL-6 significantly elevated when compare patient's pre and post dialysis. IL-2 was significantly increase in patients when compare to control.