Abstract

Platelets rich plasma (PRP) therapy proposed to be a promising option  to treat some ceases of   Non-Obstructive Azoospermia (NOA) due to its regenerative potential. The aim was To investigate the effectiveness of PRP intra-testicular therapy for male with NOA.This clinical trial included 100 men with NOA. attended to High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/ Al-Nahrain University. The diagnosis of azoospermia based on more than two semen analyses performed at least 15 days apart, testicular volume measure, and sex hormones profile study. Mean age was (34.34 ± 7. 49). First, PRP was prepared by centrifuging the patient’s own blood in the anticoagulant- tubes containing Acid Citrate Dextrose olution A (ACD-A), Second, PRP testicle   injection, repeated at least 3 times for each patient, one mouth apart. Third, micro testicular sperm extraction (TESE) was done and the presence of spermatozoa assessed under microscope.  Results show Thirty men (30%) had positive sperms retrieval.  In these cases; LH and FSH levels were significantly decreased and testosterone level was significantly increased after PRP injection. Patients with history of testicular biopsies had showed significantly higher positive spermatogenesis rate (86.7 % versus 13.3%, p value ~ 0.007). the Conclusions reveal Autologous PRP therapy has been successful rate in the treatment of some casas male infertility with NOA.