Abstract

Background: Ulcerative colitis is a chronic inflammatory disease that is linked with a large number of mortality and morbidity around the world. It causes inflammation in the colon's lining, leading to several symptoms that negatively affect the quality of life; no known cure is successful. As a result, it is imperative to investigate alternative treatment approaches. Objectives: This research aimed to assess the anti-inflammatory , anti molecular adhesion and macroscopic score impact of  ropinirole on colitis in rat modules.   Materials and Methods:  Forty adult rats were grouped into four groups for this study. These groups included the control group, which was the negative control, the acetic acid group, which was the positive control; the acetic acid + sulfasalazine (100 mg/kg per day) group; and the acetic acid + or ropinirole 10mg/kg group. The rats were treated for one week. To induce colitis, 2 ml of acetic acid (4% (v/v) was installed inter-rectally. The animals were sacrificed, and the colonic tissue homogenate was analyzed for several markers. These markers included proinflammatory cytokines (TNF-α, IL-1β, NF κB), adhesive molecule markers (E-selectin, ICAM-1), and clinical parameters. Results: sulfasalazine and ropinirole pointedly compact the level TNF-α, IL-1β, and NFκB compared with the induced colitis. Colon homogenate of TNF-α and IL-1β did not differ significantly between groups 3 and 4; however, both treatment modalities significantly ameliorated the macroscopic score compared with induced colitis with the superiority of sulfasalazine or ropinirole. Conclusions: The results indicate that ropinirole is an effective treatment for induced colitis by reducing the inflammatory response and ameliorating clinical parameter