Abstract

Background: -The most common benign lesion of the uterus are leiomyoma (fibroids) in the genital tract of the female. Uterine fibroids incidence has been assessed 30-70%. Tumor necrosis factor -α is a cell-signaling protein released in systemic inflammation. It is one of the cytokines present in acute inflammatory state in the body.
The aim of the study: - was to estimated relationship between TNF-α in female with and without uterine fibroids then evaluate the role of TNF -α and its level in clinically symptomatic women this uterine lesions (leiomyoma or the other name fibroids).
Material and methods: - overall of 97 women were included: 59 patients with uterine fibroid and 38 women without fibroid, serum TNF-α level between the two samples were matched. Mean of TNF-α in control group 5.26±3.2 pg/mL while in patients group about 17.64±5.6 pg/mL. The result was statistically significant. We found that serum TNF-α level of 7 pg/mL is used as a positive indicator for uterine fibroids in particular women. In this study, we established elevated serum TNF-α level in women which had symptoms such as pain and bleeding.
Conclusion: - In reproductive age group female, fibroids are the commonest benign gynecological lesion of uterus (30-70%). Many biological factors are reported to have an associated with them,  TNF-a , one of the important factor, which is cytokine that interfere with presence and behavior of uterine fibroid, which has major role in symptoms and complaints of patients with fibroid mostly due to inflammatory like state^.